A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing

Sarah B. Miller, F. Zehra Yildiz, Jennifer A. Lo, Bo Wang and Victoria M. D’Souza ()
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Sarah B. Miller: Harvard University
F. Zehra Yildiz: Harvard University
Jennifer A. Lo: Harvard University
Bo Wang: Harvard University
Victoria M. D’Souza: Harvard University

Nature, 2014, vol. 515, issue 7528, 591-595

Abstract: To prime reverse transcription of Moloney murine leukaemia virus, a transfer RNA molecule must bind two regions of the retroviral RNA, the primer binding site (PBS) and primer activation signal within the U5-PBS; here, the NMR structures of the U5-PBS RNA and tRNA primer are solved, with and without the retroviral nucleocapsid protein, which remodels these regions.

Date: 2014
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DOI: 10.1038/nature13709

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