MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

Thomas Powles (), Joseph Paul Eder, Gregg D. Fine, Fadi S. Braiteh, Yohann Loriot, Cristina Cruz, Joaquim Bellmunt, Howard A. Burris, Daniel P. Petrylak, Siew-leng Teng, Xiaodong Shen, Zachary Boyd, Priti S. Hegde, Daniel S. Chen and Nicholas J. Vogelzang
Additional contact information
Thomas Powles: Barts Cancer Institute, Queen Mary University of London, Barts Experimental Cancer Medicine Centre, London EC1M 6BQ, UK
Joseph Paul Eder: Yale Cancer Center, 333 Cedar Street, WWW211, New Haven, Connecticut 06520, USA
Gregg D. Fine: Genentech, Inc. 1 DNA Way
Fadi S. Braiteh: Comprehensive Cancer Centers of Nevada, 3730 S. Eastern Avenue
Yohann Loriot: Gustave Roussy, 114 Rue Édouard Vaillant, 94805 Villejuif, France
Cristina Cruz: Vall d’Hebron Institute of Oncology (VHIO) and Vall d’Hebron University Hospital. Passeig Vall d’Hebron, 119-129, 08035, Barcelona, Spain
Joaquim Bellmunt: Bladder Cancer Center, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, 450 Brookline Avenue, Boston, Massachusetts 02215, USA
Howard A. Burris: Sarah Cannon Research Institute, 3322 West End Avenue, Suite 900, Nashville, Tennessee 37203, USA
Daniel P. Petrylak: Yale Cancer Center, 333 Cedar Street, WWW211, New Haven, Connecticut 06520, USA
Siew-leng Teng: Genentech, Inc. 1 DNA Way
Xiaodong Shen: Genentech, Inc. 1 DNA Way
Zachary Boyd: Genentech, Inc. 1 DNA Way
Priti S. Hegde: Genentech, Inc. 1 DNA Way
Daniel S. Chen: Genentech, Inc. 1 DNA Way
Nicholas J. Vogelzang: University of Nevada School of Medicine and US Oncology/Comprehensive Cancer Centers of Nevada, 3730 S. Eastern Avenue

Nature, 2014, vol. 515, issue 7528, 558-562

Abstract: The results of a clinical phase I study in metastatic urothelial bladder cancer treated with the MPDL3280A antibody show that expression of PD-L1 on tumour-infiltrating immune cells is relevant for the therapeutic response.

Date: 2014
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DOI: 10.1038/nature13904

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