A positional Toll receptor code directs convergent extension in Drosophila

Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell, Avantika Mainieri and Jennifer A. Zallen ()
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Adam C. Paré: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Athea Vichas: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Christopher T. Fincher: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Zachary Mirman: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Dene L. Farrell: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Avantika Mainieri: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute
Jennifer A. Zallen: Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute

Nature, 2014, vol. 515, issue 7528, 523-527

Abstract: Abstract Elongation of the head-to-tail body axis by convergent extension is a conserved developmental process throughout metazoans. In Drosophila, patterns of transcription factor expression provide spatial cues that induce systematically oriented cell movements and promote tissue elongation. However, the mechanisms by which patterned transcriptional inputs control cell polarity and behaviour have long been elusive. We demonstrate that three Toll family receptors, Toll-2, Toll-6 and Toll-8, are expressed in overlapping transverse stripes along the anterior–posterior axis and act in combination to direct planar polarity and polarized cell rearrangements during convergent extension. Simultaneous disruption of all three receptors strongly reduces actomyosin-driven junctional remodelling and axis elongation, and an ectopic stripe of Toll receptor expression is sufficient to induce planar polarized actomyosin contractility. These results demonstrate that tissue-level patterns of Toll receptor expression provide spatial signals that link positional information from the anterior–posterior patterning system to the essential cell behaviours that drive convergent extension.

Date: 2014
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DOI: 10.1038/nature13953

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