Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Roy S. Herbst (), Jean-Charles Soria, Marcin Kowanetz, Gregg D. Fine, Omid Hamid, Michael S. Gordon, Jeffery A. Sosman, David F. McDermott, John D. Powderly, Scott N. Gettinger, Holbrook E. K. Kohrt, Leora Horn, Donald P. Lawrence, Sandra Rost, Maya Leabman, Yuanyuan Xiao, Ahmad Mokatrin, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, Daniel S. Chen and F. Stephen Hodi
Additional contact information
Roy S. Herbst: Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA
Jean-Charles Soria: Gustave Roussy South-Paris University, 114 Rue Edouard Vaillant, 94805 Villefuij, Cedex, France
Marcin Kowanetz: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Gregg D. Fine: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Omid Hamid: The Angeles Clinic and Research Institute, 11818 Wilshire Blvd
Michael S. Gordon: Pinnacle Oncology Hematology, 9055 E Del Camino Dr 100
Jeffery A. Sosman: Vanderbilt-Ingram Cancer Center, 2220 Pierce Avenue
David F. McDermott: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Shapiro 9, Boston, Massachusetts 02215, USA
John D. Powderly: Carolina BioOncology Institute, 9801 W. Kincey Ave, Suite 145, Huntersville, North Carolina 28078, USA
Scott N. Gettinger: Yale Comprehensive Cancer Center, Yale School of Medicine, 333 Cedar Street, WWW221, New Haven, Connecticut 06520, USA
Holbrook E. K. Kohrt: Stanford University, CCSR Bldg Room 1110
Leora Horn: Vanderbilt-Ingram Cancer Center, 1301 Medical Center Dr, Suite 1710, Nashville, Tennessee 37212, USA
Donald P. Lawrence: Massachusetts General Hospital, 55 Fruit Street, YAW 9E, Boston, Massachusetts 02114, USA
Sandra Rost: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Maya Leabman: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Yuanyuan Xiao: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ahmad Mokatrin: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Hartmut Koeppen: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Priti S. Hegde: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Ira Mellman: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
Daniel S. Chen: Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA
F. Stephen Hodi: Dana-Farber/Brigham and Women’s Cancer Center, 450 Brookline Avenue

Nature, 2014, vol. 515, issue 7528, 563-567

Abstract: Clinical and correlative biomarker results from a phase 1 clinical trial in patients with different solid tumours are presented; the findings indicate that PD-L1 expression on tumour-infiltrating immune cells is associated with clinical response to MPDL3280A (anti-PD-L1).

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (24)

Downloads: (external link)
https://www.nature.com/articles/nature14011 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:515:y:2014:i:7528:d:10.1038_nature14011

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature14011

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().