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The ESCRT machinery regulates the secretion and long-range activity of Hedgehog

Tamás Matusek, Franz Wendler, Sophie Polès, Sandrine Pizette, Gisela D’Angelo, Maximilian Fürthauer and Pascal P. Thérond ()
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Tamás Matusek: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Franz Wendler: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Sophie Polès: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Sandrine Pizette: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Gisela D’Angelo: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Maximilian Fürthauer: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France
Pascal P. Thérond: Université de Nice Sophia Antipolis, iBV, UMR 7277, 06100 Nice, France

Nature, 2014, vol. 516, issue 7529, 99-103

Abstract: A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion and long-range signalling of the embryonic development morphogen Hedgehog.

Date: 2014
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DOI: 10.1038/nature13847

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