Transcriptional regulation of autophagy by an FXR–CREB axis

Sunmi Seok, Ting Fu, Sung-E Choi, Yang Li, Rong Zhu, Subodh Kumar, Xiaoxiao Sun, Gyesoon Yoon, Yup Kang, Wenxuan Zhong, Jian Ma, Byron Kemper and Jongsook Kim Kemper ()
Additional contact information
Sunmi Seok: University of Illinois at Urbana-Champaign
Ting Fu: University of Illinois at Urbana-Champaign
Sung-E Choi: University of Illinois at Urbana-Champaign
Yang Li: University of Illinois at Urbana-Champaign
Rong Zhu: University of Georgia
Subodh Kumar: University of Illinois at Urbana-Champaign
Xiaoxiao Sun: University of Georgia
Gyesoon Yoon: Institute for Medical Science, Ajou University School of Medicine, Suwon 442-749, Korea
Yup Kang: Institute for Medical Science, Ajou University School of Medicine, Suwon 442-749, Korea
Wenxuan Zhong: University of Georgia
Jian Ma: University of Illinois at Urbana-Champaign
Byron Kemper: University of Illinois at Urbana-Champaign
Jongsook Kim Kemper: University of Illinois at Urbana-Champaign

Nature, 2014, vol. 516, issue 7529, 108-111

Abstract: The FXR–CREB axis is identified as a key physiological switch that regulates autophagy during feeding/fasting cycles; in the fed state, the nuclear receptor FXR is shown to suppress autophagy in the liver by inhibiting autophagy-associated lipid breakdown triggered under fasting conditions by the transcriptional activator CREB.

Date: 2014
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DOI: 10.1038/nature13949

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