TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein

Sanchita Bhatnagar, Claude Gazin, Lynn Chamberlain, Jianhong Ou, Xiaochun Zhu, Jogender S. Tushir, Ching-Man Virbasius, Ling Lin, Lihua J. Zhu, Narendra Wajapeyee and Michael R. Green ()
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Sanchita Bhatnagar: Howard Hughes Medical Institute, University of Massachusetts Medical School
Claude Gazin: CEA/DSV/iRCM/LEFG, Genopole G2, and Université Paris Diderot, 91057 Evry, France
Lynn Chamberlain: Howard Hughes Medical Institute, University of Massachusetts Medical School
Jianhong Ou: Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School
Xiaochun Zhu: Howard Hughes Medical Institute, University of Massachusetts Medical School
Jogender S. Tushir: Boehringer Ingelheim Pharmaceuticals, Inc.
Ching-Man Virbasius: Howard Hughes Medical Institute, University of Massachusetts Medical School
Ling Lin: Howard Hughes Medical Institute, University of Massachusetts Medical School
Lihua J. Zhu: Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School
Narendra Wajapeyee: Yale University School of Medicine
Michael R. Green: Howard Hughes Medical Institute, University of Massachusetts Medical School

Nature, 2014, vol. 516, issue 7529, 116-120

Abstract: The RING finger protein TRIM37 is encoded by a gene that is amplified in certain breast cancers, but its function is unknown; here, it is shown to mono-ubiquitinate histone H2A and repress gene expression, and to function as a breast cancer oncoprotein.

Date: 2014
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DOI: 10.1038/nature13955

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