Nutrient-sensing nuclear receptors coordinate autophagy

Jae Man Lee, Martin Wagner, Rui Xiao, Kang Ho Kim, Dan Feng, Mitchell A. Lazar and David D. Moore ()
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Jae Man Lee: Baylor College of Medicine
Martin Wagner: Baylor College of Medicine
Rui Xiao: Baylor College of Medicine
Kang Ho Kim: Baylor College of Medicine
Dan Feng: Diabetes, and Metabolism and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
Mitchell A. Lazar: Diabetes, and Metabolism and the Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
David D. Moore: Baylor College of Medicine

Nature, 2014, vol. 516, issue 7529, 112-115

Abstract: The nuclear receptors FXR and PPARα are shown to regulate autophagy by competing for binding to shared sites in the promoters of autophagic genes; in the fed state FXR suppresses hepatic autophagy, whereas in the fasted state PPARα is activated and reverses the normal suppression of autophagy.

Date: 2014
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DOI: 10.1038/nature13961

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