Piezo2 is the major transducer of mechanical forces for touch sensation in mice

Sanjeev S. Ranade, Seung-Hyun Woo, Adrienne E. Dubin, Rabih A. Moshourab, Christiane Wetzel, Matt Petrus, Jayanti Mathur, Valérie Bégay, Bertrand Coste, James Mainquist, A. J. Wilson, Allain G. Francisco, Kritika Reddy, Zhaozhu Qiu, John N. Wood, Gary R. Lewin and Ardem Patapoutian ()
Additional contact information
Sanjeev S. Ranade: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
Seung-Hyun Woo: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
Adrienne E. Dubin: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
Rabih A. Moshourab: Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany
Christiane Wetzel: Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany
Matt Petrus: Genomics Institute of the Novartis Research Foundation
Jayanti Mathur: Genomics Institute of the Novartis Research Foundation
Valérie Bégay: Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany
Bertrand Coste: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
James Mainquist: Genomics Institute of the Novartis Research Foundation
A. J. Wilson: Genomics Institute of the Novartis Research Foundation
Allain G. Francisco: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
Kritika Reddy: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
Zhaozhu Qiu: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute
John N. Wood: Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
Gary R. Lewin: Max-Delbrück Center for Molecular Medicine, Robert-Rössle Straße 10, D-13092 Berlin, Germany
Ardem Patapoutian: Howard Hughes Medical Institute, Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute

Nature, 2014, vol. 516, issue 7529, 121-125

Abstract: Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

Date: 2014
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DOI: 10.1038/nature13980

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