Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

Stephen G. Brohawn, Ernest B. Campbell and Roderick MacKinnon ()
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Stephen G. Brohawn: Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Ernest B. Campbell: Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Roderick MacKinnon: Laboratory of Molecular Neurobiology and Biophysics and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

Nature, 2014, vol. 516, issue 7529, 126-130

Abstract: X-ray structures of the human TRAAK mechanosensitive potassium channel reveal how build-up of tension in the lipid membrane can convert the channel from a non-conducting wedge shape associated with an inserted lipid acyl chain that blocks the pore to an expanded cross-sectional shape that prevents lipid entry and thus permits ion conduction.

Date: 2014
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DOI: 10.1038/nature14013

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