An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons

Frank M. J. Jacobs, David Greenberg, Ngan Nguyen, Maximilian Haeussler, Adam D. Ewing, Sol Katzman, Benedict Paten, Sofie R. Salama and David Haussler ()
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Frank M. J. Jacobs: Center for Biomolecular Science and Engineering, University of California Santa Cruz
David Greenberg: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Ngan Nguyen: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Maximilian Haeussler: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Adam D. Ewing: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Sol Katzman: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Benedict Paten: Center for Biomolecular Science and Engineering, University of California Santa Cruz
Sofie R. Salama: Center for Biomolecular Science and Engineering, University of California Santa Cruz
David Haussler: Center for Biomolecular Science and Engineering, University of California Santa Cruz

Nature, 2014, vol. 516, issue 7530, 242-245

Abstract: The authors show that two primate-specific genes encoding KRAB domain containing zinc finger proteins, ZNF91 and ZNF93, have evolved during the last 25 million years to repress retrotransposon families that emerged during this time period; according to the new data KZNF gene expansion limits the activity of newly emerged retrotransposons, which subsequently mutate to evade repression.

Date: 2014
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DOI: 10.1038/nature13760

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