Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

Jagan R. Muppidi, Roland Schmitz, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, Sterling E. Braun, Jinping An, Ying Xu, Andreas Rosenwald, German Ott, Randy D. Gascoyne, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Rita M. Braziel, Raymond R. Tubbs, J. R. Cook, Dennis D. Weisenburger, Wing C. Chan, Nagarajan Vaidehi, Louis M. Staudt () and Jason G. Cyster ()
Additional contact information
Jagan R. Muppidi: University of California
Roland Schmitz: Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jesse A. Green: University of California
Wenming Xiao: Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Adrien B. Larsen: Beckman Research Institute of the City of Hope
Sterling E. Braun: University of California
Jinping An: University of California
Ying Xu: University of California
Andreas Rosenwald: University of Würzburg, 97080 Würzburg, Germany
German Ott: Robert-Bosch-Krankenhaus, Auerbachstraße 110, 70376 Stuttgart, Germany
Randy D. Gascoyne: British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
Lisa M. Rimsza: University of Arizona
Elias Campo: Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
Elaine S. Jaffe: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jan Delabie: Pathology Clinic, Rikshospitalet University Hospital, 0372 Oslo, Norway
Erlend B. Smeland: Institute for Cancer Research, Rikshospitalet University Hospital, University of Oslo, 0310 Oslo, Norway
Rita M. Braziel: Oregon Health and Science University
Raymond R. Tubbs: Cleveland Clinic Pathology and Laboratory Medicine Institute
J. R. Cook: Cleveland Clinic Pathology and Laboratory Medicine Institute
Dennis D. Weisenburger: City of Hope National Medical Center
Wing C. Chan: University of Nebraska Medical Center
Nagarajan Vaidehi: Beckman Research Institute of the City of Hope
Louis M. Staudt: Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
Jason G. Cyster: University of California

Nature, 2014, vol. 516, issue 7530, 254-258

Abstract: Inactivation of the S1PR2–Gα13–ARHGEF1 signalling pathway in mice allows Akt activation and promotes dissemination of germinal centre B cells, consistent with a role of function-disrupting mutations in the systemic dissemination of diffuse large B-cell lymphoma.

Date: 2014
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DOI: 10.1038/nature13765

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