Dietary modulation of the microbiome affects autoinflammatory disease

John R. Lukens, Prajwal Gurung, Peter Vogel, Gordon R. Johnson, Robert A. Carter, Daniel J. McGoldrick, Srinivasa Rao Bandi, Christopher R. Calabrese, Lieselotte Vande Walle, Mohamed Lamkanfi and Thirumala-Devi Kanneganti ()
Additional contact information
John R. Lukens: St Jude Children’s Research Hospital
Prajwal Gurung: St Jude Children’s Research Hospital
Peter Vogel: Animal Resources Center and the Veterinary Pathology Core, St Jude Children’s Research Hospital
Gordon R. Johnson: St Jude Children’s Research Hospital
Robert A. Carter: Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital
Daniel J. McGoldrick: Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital
Srinivasa Rao Bandi: St Jude Children’s Research Hospital
Christopher R. Calabrese: Small Animal Imaging Core, St Jude Children’s Research Hospital
Lieselotte Vande Walle: VIB, B-9000 Ghent, Belgium
Mohamed Lamkanfi: VIB, B-9000 Ghent, Belgium
Thirumala-Devi Kanneganti: St Jude Children’s Research Hospital

Nature, 2014, vol. 516, issue 7530, 246-249

Abstract: Pstpip2-mutant mice fed a high-fat diet are protected against inflammatory bone disease and bone erosion; this protection is associated with reductions in intestinal Prevotella levels and pro-IL-1β expression, and is dependent on the deletion of both caspases 1 and 8.

Date: 2014
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DOI: 10.1038/nature13788

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