Rapid development of broadly influenza neutralizing antibodies through redundant mutations

Leontios Pappas, Mathilde Foglierini, Luca Piccoli, Nicole L. Kallewaard, Filippo Turrini, Chiara Silacci, Blanca Fernandez-Rodriguez, Gloria Agatic, Isabella Giacchetto-Sasselli, Gabriele Pellicciotta, Federica Sallusto, Qing Zhu, Elisa Vicenzi, Davide Corti and Antonio Lanzavecchia ()
Additional contact information
Leontios Pappas: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Mathilde Foglierini: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Luca Piccoli: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Nicole L. Kallewaard: One MedImmune Way
Filippo Turrini: Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Chiara Silacci: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Blanca Fernandez-Rodriguez: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Gloria Agatic: Humabs BioMed SA, Via Mirasole 1, 6500 Bellinzona, Switzerland
Isabella Giacchetto-Sasselli: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Gabriele Pellicciotta: Unit of Preventive Medicine, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Federica Sallusto: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Qing Zhu: One MedImmune Way
Elisa Vicenzi: Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Davide Corti: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland
Antonio Lanzavecchia: Insitute for Research in Biomedicine, Università della Svizzera Italiana, Via Vincenzo Vela 6, 6500 Bellinzona, Switzerland

Nature, 2014, vol. 516, issue 7531, 418-422

Abstract: The main pathway of somatic mutations leading to the generation of high affinity broadly neutralizing antibodies against the influenza haemagglutinin stem is defined.

Date: 2014
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DOI: 10.1038/nature13764

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