R-loops induce repressive chromatin marks over mammalian gene terminators

Konstantina Skourti-Stathaki, Kinga Kamieniarz-Gdula and Nicholas J. Proudfoot ()
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Konstantina Skourti-Stathaki: Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK
Kinga Kamieniarz-Gdula: Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK
Nicholas J. Proudfoot: Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK

Nature, 2014, vol. 516, issue 7531, 436-439

Abstract: R-loops, which have been considered to be rare and potentially harmful transcriptional by-products, are now shown to be needed for antisense transcription and to induce repressive chromatin marks that reinforce pausing of transcription and thereby enhance its termination.

Date: 2014
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DOI: 10.1038/nature13787

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