Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

Jichang Wang, Gangcai Xie, Manvendra Singh, Avazeh T. Ghanbarian, Tamás Raskó, Attila Szvetnik, Huiqiang Cai, Daniel Besser, Alessandro Prigione, Nina V. Fuchs, Gerald G. Schumann, Wei Chen, Matthew C. Lorincz, Zoltán Ivics, Laurence D. Hurst () and Zsuzsanna Izsvák ()
Additional contact information
Jichang Wang: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Gangcai Xie: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Manvendra Singh: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Avazeh T. Ghanbarian: University of Bath, Bath, Somerset BA2 7AY, UK
Tamás Raskó: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Attila Szvetnik: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Huiqiang Cai: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Daniel Besser: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Alessandro Prigione: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Nina V. Fuchs: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Gerald G. Schumann: Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany
Wei Chen: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany
Matthew C. Lorincz: University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Zoltán Ivics: Paul-Ehrlich-Institute, Paul-Ehrlich-Strasse 51-59, 63225 Langen, Germany
Laurence D. Hurst: University of Bath, Bath, Somerset BA2 7AY, UK
Zsuzsanna Izsvák: Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13125 Berlin, Germany

Nature, 2014, vol. 516, issue 7531, 405-409

Abstract: An extensive analysis of HERVH (a primate-specific endogenous retrovirus) expression in human pluripotent stem cells is presented, identifying a sub-population of cells within cultured human embryonic stem cells and induced pluripotent stem cells that has characteristics of naive-state cells — the study provides evidence for a new primate-specific transcriptional circuitry regulating pluripotency.

Date: 2014
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DOI: 10.1038/nature13804

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