Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

Mark W. Pellegrino, Amrita M. Nargund, Natalia V. Kirienko, Reba Gillis, Christopher J. Fiorese and Cole M. Haynes ()
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Mark W. Pellegrino: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Amrita M. Nargund: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Natalia V. Kirienko: Massachusetts General Hospital
Reba Gillis: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
Christopher J. Fiorese: BCMB Allied Program, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
Cole M. Haynes: Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA

Nature, 2014, vol. 516, issue 7531, 414-417

Abstract: A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activation of the transcription factor ATFS-1 and innate immunity that is regulated by the mitochondrial unfolded protein response.

Date: 2014
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DOI: 10.1038/nature13818

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