Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe

Takeshi Mizuguchi, Geoffrey Fudenberg, Sameet Mehta, Jon-Matthew Belton, Nitika Taneja, Hernan Diego Folco, Peter FitzGerald, Job Dekker, Leonid Mirny, Jemima Barrowman and Shiv I. S. Grewal ()
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Takeshi Mizuguchi: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Geoffrey Fudenberg: Graduate Program in Biophysics, Harvard University
Sameet Mehta: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Jon-Matthew Belton: Program in Systems Biology, University of Massachusetts Medical School
Nitika Taneja: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Hernan Diego Folco: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Peter FitzGerald: Genome Analysis Unit, National Cancer Institute, National Institutes of Health
Job Dekker: Program in Systems Biology, University of Massachusetts Medical School
Leonid Mirny: Graduate Program in Biophysics, Harvard University
Jemima Barrowman: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health
Shiv I. S. Grewal: Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health

Nature, 2014, vol. 516, issue 7531, 432-435

Abstract: Genome-wide chromatin conformation capture (Hi-C) is used to investigate three-dimensional genome organization in Schizosaccharomyces pombe; small domains of chromatin interact locally on chromosome arms to form globules, which depend on cohesin but not heterochromatin for formation, and heterochromatin at centromeres and telomeres provides crucial structural constraints to shape genome architecture.

Date: 2014
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DOI: 10.1038/nature13833

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