Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Kyle W. McCracken, Emily M. Catá, Calyn M. Crawford, Katie L. Sinagoga, Michael Schumacher, Briana E. Rockich, Yu-Hwai Tsai, Christopher N. Mayhew, Jason R. Spence, Yana Zavros () and James M. Wells ()
Additional contact information
Kyle W. McCracken: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Emily M. Catá: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Calyn M. Crawford: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Katie L. Sinagoga: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Michael Schumacher: University of Cincinnati
Briana E. Rockich: University of Michigan Medical School
Yu-Hwai Tsai: University of Michigan Medical School
Christopher N. Mayhew: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA
Jason R. Spence: University of Michigan Medical School
Yana Zavros: University of Cincinnati
James M. Wells: Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA

Nature, 2014, vol. 516, issue 7531, 400-404

Abstract: The in vitro generation, from pluripotent stem cells, of three-dimensional human gastric organoids (hGOs) that contain a physiological gastric epithelium comprising both progenitor and differentiated cell types, and have expected functional characteristics is described, as is modelling the pathophysiological response of the human stomach to Helicobacter pylori using these hGOs.

Date: 2014
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DOI: 10.1038/nature13863

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