Rapid modelling of cooperating genetic events in cancer through somatic genome editing

Francisco J. Sánchez-Rivera, Thales Papagiannakopoulos, Rodrigo Romero, Tuomas Tammela, Matthew R. Bauer, Arjun Bhutkar, Nikhil S. Joshi, Lakshmipriya Subbaraj, Roderick T. Bronson, Wen Xue and Tyler Jacks ()
Additional contact information
Francisco J. Sánchez-Rivera: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Thales Papagiannakopoulos: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Rodrigo Romero: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Tuomas Tammela: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Matthew R. Bauer: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Arjun Bhutkar: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Nikhil S. Joshi: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Lakshmipriya Subbaraj: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Roderick T. Bronson: Tufts University
Wen Xue: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Tyler Jacks: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

Nature, 2014, vol. 516, issue 7531, 428-431

Abstract: The CRISPR/Cas system has been used in mice for genome editing to introduce genetic alterations found in human lung tumours, and these genome modifications resulted in mouse lung tumours showing different histopathologies depending on the genes altered; the CRISPR/Cas system offers improved and faster ways to create animal models of human diseases such as cancer.

Date: 2014
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DOI: 10.1038/nature13906

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