Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum

Xiaochun Li (), Rita Roberti and Günter Blobel ()
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Xiaochun Li: Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University
Rita Roberti: University of Perugia, Perugia 06132, Italy
Günter Blobel: Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University

Nature, 2015, vol. 517, issue 7532, 104-107

Abstract: Solving the X-ray crystal structure of a Δ14-sterol reductase and homologue of human C14SR and DHCR7, two enzymes that reduce specific carbon–carbon double bonds in the cholesterol biosynthetic pathway, may provide insight into how specific mutations in DHCR7 and lamin B receptor lead to human diseases.

Date: 2015
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DOI: 10.1038/nature13797

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