Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

Xianqin Zhang, Dusan Bogunovic (), Béatrice Payelle-Brogard, Véronique Francois-Newton, Scott D. Speer, Chao Yuan, Stefano Volpi, Zhi Li, Ozden Sanal, Davood Mansouri, Ilhan Tezcan, Gillian I. Rice, Chunyuan Chen, Nahal Mansouri, Seyed Alireza Mahdaviani, Yuval Itan, Bertrand Boisson, Satoshi Okada, Lu Zeng, Xing Wang, Hui Jiang, Wenqiang Liu, Tiantian Han, Delin Liu, Tao Ma, Bo Wang, Mugen Liu, Jing-Yu Liu, Qing K. Wang, Dilek Yalnizoglu, Lilliana Radoshevich, Gilles Uzé, Philippe Gros, Flore Rozenberg, Shen-Ying Zhang, Emmanuelle Jouanguy, Jacinta Bustamante, Adolfo García-Sastre, Laurent Abel, Pierre Lebon, Luigi D. Notarangelo, Yanick J. Crow, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova and Sandra Pellegrini
Additional contact information
Xianqin Zhang: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Dusan Bogunovic: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Béatrice Payelle-Brogard: Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France
Véronique Francois-Newton: Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France
Scott D. Speer: Icahn School of Medicine at Mount Sinai
Chao Yuan: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Stefano Volpi: Children’s Hospital Boston
Zhi Li: Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France
Ozden Sanal: Hacettepe University Children’s Hospital, 06100 Ankara, Turkey
Davood Mansouri: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran
Ilhan Tezcan: Hacettepe University Children’s Hospital, 06100 Ankara, Turkey
Gillian I. Rice: Manchester Academic Health Science Centre, University of Manchester, Genetic Medicine, Manchester, M13 9NT, UK
Chunyuan Chen: Third Xiangya Hospital, Central South University, Changsha 410013, China
Nahal Mansouri: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran
Seyed Alireza Mahdaviani: Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, 4739 Teheran, Iran
Yuval Itan: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Bertrand Boisson: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Satoshi Okada: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Lu Zeng: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Xing Wang: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Hui Jiang: BGI-Shenzhen
Wenqiang Liu: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Tiantian Han: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Delin Liu: Sangzhi County People's Hospital
Tao Ma: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Bo Wang: Genetics Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, Hubei 430070, China
Mugen Liu: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Jing-Yu Liu: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Qing K. Wang: Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology
Dilek Yalnizoglu: Hacettepe University Children’s Hospital, 06100 Ankara, Turkey
Lilliana Radoshevich: Institut Pasteur, Bacteria-Cell Interactions Unit, 75724 Paris, France
Gilles Uzé: CNRS UMR5235, Montpellier II University, Place Eugène Bataillon, 34095 Montpellier, France
Philippe Gros: McGill University, Montreal, QC H3A 0G4, Canada
Flore Rozenberg: Paris Descartes University, 75006 Paris, France
Shen-Ying Zhang: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Emmanuelle Jouanguy: Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
Jacinta Bustamante: Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, 75015 Paris, France
Adolfo García-Sastre: Icahn School of Medicine at Mount Sinai
Laurent Abel: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Pierre Lebon: Paris Descartes University, 75006 Paris, France
Luigi D. Notarangelo: Children’s Hospital Boston
Yanick J. Crow: Manchester Academic Health Science Centre, University of Manchester, Genetic Medicine, Manchester, M13 9NT, UK
Stéphanie Boisson-Dupuis: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Jean-Laurent Casanova: St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University
Sandra Pellegrini: Institut Pasteur, Cytokine Signaling Unit, CNRS URA 1961, 75724 Paris, France

Nature, 2015, vol. 517, issue 7532, 89-93

Abstract: ISG15 deficiency in humans leads to a failure to maintain adequate levels of USP18, triggering an increase in type I interferon production and signalling, and promoting auto-inflammatory disease.

Date: 2015
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DOI: 10.1038/nature13801

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