Hepatitis A virus and the origins of picornaviruses

Xiangxi Wang, Jingshan Ren, Qiang Gao, Zhongyu Hu, Yao Sun, Xuemei Li, David J. Rowlands, Weidong Yin, Junzhi Wang (), David I. Stuart (), Zihe Rao () and Elizabeth E. Fry
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Xiangxi Wang: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
Jingshan Ren: University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK
Qiang Gao: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
Zhongyu Hu: National Institutes for Food and Drug Control, No. 2, TiantanXili, Beijing 100050, China
Yao Sun: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
Xuemei Li: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
David J. Rowlands: Institute of Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
Weidong Yin: Sinovac Biotech Co., Ltd
Junzhi Wang: National Institutes for Food and Drug Control, No. 2, TiantanXili, Beijing 100050, China
David I. Stuart: University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK
Zihe Rao: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science
Elizabeth E. Fry: University of Oxford, The Henry Wellcome Building for Genomic Medicine, Headington, Oxford OX3 7BN, UK

Nature, 2015, vol. 517, issue 7532, 85-88

Abstract: Hepatitis A virus is a picornavirus that causes significant morbidity but remains poorly understood; this paper now provides high-resolution crystal structures of both the mature and the empty hepatitis A virus particle, which show that the three-dimensional structure resembles insect picorna-like viruses.

Date: 2015
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DOI: 10.1038/nature13806

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