A PP1–PP2A phosphatase relay controls mitotic progression

Agnes Grallert, Elvan Boke, Anja Hagting, Ben Hodgson, Yvonne Connolly, John R. Griffiths, Duncan L. Smith, Jonathon Pines and Iain M. Hagan ()
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Agnes Grallert: CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Elvan Boke: CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Anja Hagting: The Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QN, UK
Ben Hodgson: CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Yvonne Connolly: Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
John R. Griffiths: Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Duncan L. Smith: Biological Mass Spectrometry, CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Jonathon Pines: The Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge, CB2 1QN, UK
Iain M. Hagan: CRUK Manchester Institute, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK

Nature, 2015, vol. 517, issue 7532, 94-98

Abstract: The activation and coordination of phosphatase activity is important during mitotic exit; here, a mitotic phosphatase relay is described in fission yeast between the two major phosphatases, PP1 and PP2A, a mode of regulation that may be a feature of signalling networks across eukaryotes.

Date: 2015
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DOI: 10.1038/nature14019

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