T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Dan Liu, Heping Xu, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo and Hai Qi ()
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Dan Liu: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Heping Xu: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Changming Shih: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Zurong Wan: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Xiaopeng Ma: School of Life Sciences, Tsinghua University
Weiwei Ma: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Dan Luo: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Hai Qi: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University

Nature, 2015, vol. 517, issue 7533, 214-218

Abstract: Interactions between T and B cells in the germinal centre are brief but involve extensive cell-surface contact in an entangled mode; ICOSL promotes T–B entanglement and B-cell acquisition of CD40L, which drives B cells to upregulate ICOSL, thus forming an intercellular feed-forward loop that is required for efficient positive selection and development of the bone marrow plasma cell compartment.

Date: 2015
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DOI: 10.1038/nature13803

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