Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Charlie G. Buffie, Vanni Bucci, Richard R. Stein, Peter T. McKenney, Lilan Ling, Asia Gobourne, Daniel No, Hui Liu, Melissa Kinnebrew, Agnes Viale, Eric Littmann, Marcel R. M. van den Brink, Robert R. Jenq, Ying Taur, Chris Sander, Justin R. Cross, Nora C. Toussaint, Joao B. Xavier and Eric G. Pamer ()
Additional contact information
Charlie G. Buffie: Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
Vanni Bucci: Computational Biology Program, Sloan-Kettering Institute
Richard R. Stein: Computational Biology Program, Sloan-Kettering Institute
Peter T. McKenney: Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
Lilan Ling: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Asia Gobourne: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Daniel No: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Hui Liu: Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan-Kettering Institute
Melissa Kinnebrew: Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
Agnes Viale: Genomics Core Laboratory, Sloan-Kettering Institute
Eric Littmann: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Marcel R. M. van den Brink: Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center
Robert R. Jenq: Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center
Ying Taur: Infectious Diseases Service, Memorial Sloan Kettering Cancer Center
Chris Sander: Computational Biology Program, Sloan-Kettering Institute
Justin R. Cross: Donald B. and Catherine C. Marron Cancer Metabolism Center, Sloan-Kettering Institute
Nora C. Toussaint: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Joao B. Xavier: Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center
Eric G. Pamer: Infectious Diseases Service, Memorial Sloan Kettering Cancer Center

Nature, 2015, vol. 517, issue 7533, 205-208

Abstract: A fraction of the intestinal microbiota as precise as a single bacterial species confers infection resistance by synthesizing Clostridium difficile-inhibiting metabolites from host-derived bile salts.

Date: 2015
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DOI: 10.1038/nature13828

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