EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

Brent Neumann, Sean Coakley, Rosina Giordano-Santini, Casey Linton, Eui Seung Lee, Akihisa Nakagawa, Ding Xue and Massimo A. Hilliard ()
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Brent Neumann: CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Sean Coakley: CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Rosina Giordano-Santini: CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Casey Linton: CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia
Eui Seung Lee: Cellular, and Developmental Biology, University of Colorado
Akihisa Nakagawa: Cellular, and Developmental Biology, University of Colorado
Ding Xue: Cellular, and Developmental Biology, University of Colorado
Massimo A. Hilliard: CJCADR, Queensland Brain Institute, The University of Queensland, Brisbane QLD 4072, Australia

Nature, 2015, vol. 517, issue 7533, 219-222

Abstract: Unlike the limited post-injury neuronal regeneration in humans, severed axons in C. elegans can regenerate through a cellular fusion mechanism; this study identifies the molecular basis for this process which includes phosphatidylserine recognition and a role for specific molecules that also act in apoptosis.

Date: 2015
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DOI: 10.1038/nature14102

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