CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

Yu-Hwa Huang, Chen Zhu, Yasuyuki Kondo, Ana C. Anderson, Amit Gandhi, Andrew Russell, Stephanie K. Dougan, Britt-Sabina Petersen, Espen Melum, Thomas Pertel, Kiera L. Clayton, Monika Raab, Qiang Chen, Nicole Beauchemin, Paul J. Yazaki, Michal Pyzik, Mario A. Ostrowski, Jonathan N. Glickman, Christopher E. Rudd, Hidde L. Ploegh, Andre Franke, Gregory A. Petsko, Vijay K. Kuchroo and Richard S. Blumberg ()
Additional contact information
Yu-Hwa Huang: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Chen Zhu: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Yasuyuki Kondo: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Ana C. Anderson: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Amit Gandhi: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Andrew Russell: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
Stephanie K. Dougan: Whitehead Institute, Massachusetts Institute of Technology
Britt-Sabina Petersen: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany
Espen Melum: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Thomas Pertel: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Kiera L. Clayton: University of Toronto, Toronto, Ontario M5S1A8, Canada
Monika Raab: Cell Signalling Section, University of Cambridge, Cambridge CB2 1QP, UK
Qiang Chen: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Nicole Beauchemin: Goodman Cancer Research Centre, McGill University, Montreal H3G 1Y6, Canada
Paul J. Yazaki: Beckman Institute, City of Hope
Michal Pyzik: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA
Mario A. Ostrowski: University of Toronto, Toronto, Ontario M5S1A8, Canada
Jonathan N. Glickman: GI Pathology, Miraca Life Sciences
Christopher E. Rudd: Cell Signalling Section, University of Cambridge, Cambridge CB2 1QP, UK
Hidde L. Ploegh: Whitehead Institute, Massachusetts Institute of Technology
Andre Franke: Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel 24105, Germany
Gregory A. Petsko: Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
Vijay K. Kuchroo: Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women’s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Richard S. Blumberg: Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA

Nature, 2015, vol. 517, issue 7534, 386-390

Abstract: CEACAM1 functions as a novel heterophilic ligand for TIM-3 and is necessary for TIM-3-mediated tolerance, which has marked consequences for inflammation, infection and cancer.

Date: 2015
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DOI: 10.1038/nature13848

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