Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

Kai Deng, Mihaela Pertea, Anthony Rongvaux, Leyao Wang, Christine M. Durand, Gabriel Ghiaur, Jun Lai, Holly L. McHugh, Haiping Hao, Hao Zhang, Joseph B. Margolick, Cagan Gurer, Andrew J. Murphy, David M. Valenzuela, George D. Yancopoulos, Steven G. Deeks, Till Strowig, Priti Kumar, Janet D. Siliciano, Steven L. Salzberg, Richard A. Flavell (), Liang Shan () and Robert F. Siliciano ()
Additional contact information
Kai Deng: Johns Hopkins University School of Medicine
Mihaela Pertea: Johns Hopkins University School of Medicine
Anthony Rongvaux: Yale University School of Medicine
Leyao Wang: Yale School of Public Health
Christine M. Durand: Johns Hopkins University School of Medicine
Gabriel Ghiaur: Johns Hopkins University School of Medicine
Jun Lai: Johns Hopkins University School of Medicine
Holly L. McHugh: Johns Hopkins University School of Medicine
Haiping Hao: Deep Sequencing and Microarray Core, Johns Hopkins University School of Medicine
Hao Zhang: Johns Hopkins Bloomberg School of Public Health
Joseph B. Margolick: Johns Hopkins Bloomberg School of Public Health
Cagan Gurer: Regeneron Pharmaceuticals Inc.
Andrew J. Murphy: Regeneron Pharmaceuticals Inc.
David M. Valenzuela: Regeneron Pharmaceuticals Inc.
George D. Yancopoulos: Regeneron Pharmaceuticals Inc.
Steven G. Deeks: University of California, San Francisco, San Francisco, California 94110, USA
Till Strowig: Yale University School of Medicine
Priti Kumar: Yale University School of Medicine
Janet D. Siliciano: Johns Hopkins University School of Medicine
Steven L. Salzberg: Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Richard A. Flavell: Yale University School of Medicine
Liang Shan: Yale University School of Medicine
Robert F. Siliciano: Johns Hopkins University School of Medicine

Nature, 2015, vol. 517, issue 7534, 381-385

Abstract: Despite receiving antiretroviral therapy, most patients with HIV still have latent reservoirs of the virus; here, these reservoirs are shown to be dominated by viruses with cytotoxic T lymphocyte escape mutations, with potential implications for the development of therapeutic vaccines.

Date: 2015
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DOI: 10.1038/nature14053

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