Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation

Hengzhi You, Emeline Rideau, Mireia Sidera and Stephen P. Fletcher ()
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Hengzhi You: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
Emeline Rideau: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
Mireia Sidera: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK
Stephen P. Fletcher: Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK

Nature, 2015, vol. 517, issue 7534, 351-355

Abstract: A copper-catalysed dynamic kinetic asymmetric transformation using racemic substrates and alkyl nucleophiles is reported; organometallic reagents are generated in situ from alkenes by hydrometallation, and give highly enantioenriched products under mild reaction conditions.

Date: 2015
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DOI: 10.1038/nature14089

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