The biology of innate lymphoid cells

David Artis () and Hergen Spits ()
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David Artis: Weill Cornell Medical College, Cornell University
Hergen Spits: Academic Medical Center at the University of Amsterdam

Nature, 2015, vol. 517, issue 7534, 293-301

Abstract: Abstract The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer.

Date: 2015
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DOI: 10.1038/nature14189

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