Structure of the immature HIV-1 capsid in intact virus particles at 8.8 Å resolution

Florian K. M. Schur, Wim J. H. Hagen, Michaela Rumlová, Tomáš Ruml, Barbara Müller, Hans-Georg Kräusslich and John A. G. Briggs ()
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Florian K. M. Schur: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Wim J. H. Hagen: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Michaela Rumlová: Institute of Organic Chemistry and Biochemistry (IOCB), Academy of Sciences of the Czech Republic, v.v.i., IOCB & Gilead Research Center, Flemingovo nám. 2, 166 10 Prague, Czech Republic
Tomáš Ruml: Institute of Chemical Technology, Prague, Technická 5, 166 28, Prague, Czech Republic
Barbara Müller: Molecular Medicine Partnership Unit, European Molecular Biology Laboratory/Universitätsklinikum Heidelberg
Hans-Georg Kräusslich: Molecular Medicine Partnership Unit, European Molecular Biology Laboratory/Universitätsklinikum Heidelberg
John A. G. Briggs: Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany

Nature, 2015, vol. 517, issue 7535, 505-508

Abstract: Cryo-electron tomography and subtomogram averaging methods reveal the structure of the capsid lattice within intact heterogeneous immature HIV-1 particles.

Date: 2015
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DOI: 10.1038/nature13838

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