mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

William J. Faller, Thomas J. Jackson, John R. P. Knight, Rachel A. Ridgway, Thomas Jamieson, Saadia A. Karim, Carolyn Jones, Sorina Radulescu, David J. Huels, Kevin B. Myant, Kate M. Dudek, Helen A. Casey, Alessandro Scopelliti, Julia B. Cordero, Marcos Vidal, Mario Pende, Alexey G. Ryazanov, Nahum Sonenberg, Oded Meyuhas, Michael N. Hall, Martin Bushell, Anne E. Willis and Owen J. Sansom ()
Additional contact information
William J. Faller: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Thomas J. Jackson: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
John R. P. Knight: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
Rachel A. Ridgway: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Thomas Jamieson: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Saadia A. Karim: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Carolyn Jones: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
Sorina Radulescu: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
David J. Huels: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Kevin B. Myant: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Kate M. Dudek: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
Helen A. Casey: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Alessandro Scopelliti: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Julia B. Cordero: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Marcos Vidal: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK
Mario Pende: Institut Necker-Enfants Malades, CS 61431, Paris, France Institut National de la Santé et de la Recherche Médicale, U1151, F-75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
Alexey G. Ryazanov: Rutgers The State University of New Jersey, Robert Wood Johnson Medical School
Nahum Sonenberg: McGill University, Montreal, Québec H3A 1A3, Canada
Oded Meyuhas: IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel
Michael N. Hall: Biozentrum, University of Basel, CH-4056 Basel, Switzerland
Martin Bushell: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
Anne E. Willis: Medical Research Council Toxicology Unit, Leicester LE1 9HN, UK
Owen J. Sansom: Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK

Nature, 2015, vol. 517, issue 7535, 497-500

Abstract: The mTORC1 complex has been implicated in tumorigenesis owing partially to its ability to increase protein translation; now, mTORC1 activity in the mouse intestine is shown not to be required for normal homeostasis but to be necessary for the triggering of tumorigenesis by APC mutations, suggesting that it could be a good target for the prevention of colorectal cancer in high-risk patients.

Date: 2015
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DOI: 10.1038/nature13896

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