The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

Peter M. K. Westcott, Kyle D. Halliwill, Minh D. To, Mamunur Rashid, Alistair G. Rust, Thomas M. Keane, Reyno Delrosario, Kuang-Yu Jen, Kay E. Gurley, Christopher J. Kemp, Erik Fredlund, David A. Quigley, David J. Adams and Allan Balmain ()
Additional contact information
Peter M. K. Westcott: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Kyle D. Halliwill: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Minh D. To: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Mamunur Rashid: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Alistair G. Rust: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Thomas M. Keane: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Reyno Delrosario: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Kuang-Yu Jen: University of California San Francisco
Kay E. Gurley: Fred Hutchinson Cancer Research Center
Christopher J. Kemp: Fred Hutchinson Cancer Research Center
Erik Fredlund: Science for Life Laboratory, Karolinska Institute, Stockholm 171 21, Sweden
David A. Quigley: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
David J. Adams: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Allan Balmain: Helen Diller Family Comprehensive Cancer Center, University of California San Francisco

Nature, 2015, vol. 517, issue 7535, 489-492

Abstract: Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by exposure to carcinogens or by genetic mutation of Kras; the results reveal that the two types of tumour have different mutational profiles and adopt different routes to tumour development.

Date: 2015
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature13898 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:517:y:2015:i:7535:d:10.1038_nature13898

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13898

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().