Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis

Henri-François Renard, Mijo Simunovic, Joël Lemière, Emmanuel Boucrot, Maria Daniela Garcia-Castillo, Senthil Arumugam, Valérie Chambon, Christophe Lamaze, Christian Wunder, Anne K. Kenworthy, Anne A. Schmidt, Harvey T. McMahon, Cécile Sykes, Patricia Bassereau and Ludger Johannes ()
Additional contact information
Henri-François Renard: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Mijo Simunovic: Institut Curie — Centre de Recherche, Membrane and Cell Functions group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Joël Lemière: Institut Curie — Centre de Recherche, Biomimetism of Cell Movement group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Emmanuel Boucrot: Institute of Structural and Molecular Biology, University College London & Birkbeck College, London WC1E 6BT, UK
Maria Daniela Garcia-Castillo: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Senthil Arumugam: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Valérie Chambon: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Christophe Lamaze: CNRS UMR3666, 75005 Paris, France
Christian Wunder: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Anne K. Kenworthy: Vanderbilt School of Medicine, 718 Light Hall, Nashville, Tennessee 37232, USA
Anne A. Schmidt: CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Hélène Brion, 75205 Paris Cedex 13, France
Harvey T. McMahon: Medical Research Council, Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK
Cécile Sykes: Institut Curie — Centre de Recherche, Biomimetism of Cell Movement group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Patricia Bassereau: Institut Curie — Centre de Recherche, Membrane and Cell Functions group, CNRS UMR 168, Physico-Chimie Curie, Université Pierre et Marie Curie, 26 rue d’Ulm, 75248 Paris Cedex 05, France
Ludger Johannes: Institut Curie — Centre de Recherche, Endocytic Trafficking and Therapeutic Delivery group, 26 rue d’Ulm, 75248 Paris Cedex 05, France

Nature, 2015, vol. 517, issue 7535, 493-496

Abstract: Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

Date: 2015
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DOI: 10.1038/nature14064

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