Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

Bret D. Freudenthal, William A. Beard, Lalith Perera, David D. Shock, Taejin Kim, Tamar Schlick and Samuel H. Wilson ()
Additional contact information
Bret D. Freudenthal: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA
William A. Beard: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA
Lalith Perera: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA
David D. Shock: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA
Taejin Kim: New York University, and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 10th Floor Silver Center, 100 Washington Square East, New York, New York 10003, USA
Tamar Schlick: New York University, and NYU-ECNU Center for Computational Chemistry at NYU Shanghai, 10th Floor Silver Center, 100 Washington Square East, New York, New York 10003, USA
Samuel H. Wilson: Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, North Carolina 27709-2233, USA

Nature, 2015, vol. 517, issue 7536, 635-639

Abstract: Time--β bound to substrate DNA as it inserts 8-oxo-dGTP opposite either cytosine or adenine.

Date: 2015
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DOI: 10.1038/nature13886

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