Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

Xue Guo, Ling Wang, Jie Li, Zhanyu Ding, Jianxiong Xiao, Xiaotong Yin, Shuang He, Pan Shi, Liping Dong, Guohong Li, Changlin Tian, Jiawei Wang, Yao Cong and Yanhui Xu ()
Additional contact information
Xue Guo: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Ling Wang: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Jie Li: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Zhanyu Ding: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Jianxiong Xiao: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Xiaotong Yin: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Shuang He: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University
Pan Shi: High Magnetic Field Laboratory, Chinese Academy of Sciences
Liping Dong: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science
Guohong Li: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science
Changlin Tian: High Magnetic Field Laboratory, Chinese Academy of Sciences
Jiawei Wang: State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University
Yao Cong: National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Yanhui Xu: Fudan University Shanghai Cancer Center, Institute of Biomedical Sciences, Shanghai Medical College of Fudan University

Nature, 2015, vol. 517, issue 7536, 640-644

Abstract: A working model for histone H3-induced dynamic regulation of the de novo DNA methyltransferase.

Date: 2015
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DOI: 10.1038/nature13899

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