p63+Krt5+ distal airway stem cells are essential for lung regeneration

Wei Zuo, Ting Zhang, Daniel Zheng'An Wu, Shou Ping Guan, Audrey-Ann Liew, Yusuke Yamamoto, Xia Wang, Siew Joo Lim, Matthew Vincent, Mark Lessard, Christopher P. Crum, Wa Xian () and Frank McKeon ()
Additional contact information
Wei Zuo: Genome Institute of Singapore, A-STAR, 138672 Singapore
Ting Zhang: Genome Institute of Singapore, A-STAR, 138672 Singapore
Daniel Zheng'An Wu: Genome Institute of Singapore, A-STAR, 138672 Singapore
Shou Ping Guan: Genome Institute of Singapore, A-STAR, 138672 Singapore
Audrey-Ann Liew: Genome Institute of Singapore, A-STAR, 138672 Singapore
Yusuke Yamamoto: The Jackson Laboratory for Genomic Medicine
Xia Wang: The Jackson Laboratory for Genomic Medicine
Siew Joo Lim: Genome Institute of Singapore, A-STAR, 138672 Singapore
Matthew Vincent: Advanced Cell Technologies
Mark Lessard: The Jackson Laboratory
Christopher P. Crum: Brigham and Women’s Hospital, Harvard Medical School
Wa Xian: Genome Institute of Singapore, A-STAR, 138672 Singapore
Frank McKeon: Genome Institute of Singapore, A-STAR, 138672 Singapore

Nature, 2015, vol. 517, issue 7536, 616-620

Abstract: Many patients experiencing sudden loss of lung tissue somehow undergo full recovery; here this recovery is traced to a discrete population of lung stem cells that are not only essential for lung regeneration but can be cloned and then transplanted to other mice to contribute new lung tissue.

Date: 2015
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DOI: 10.1038/nature13903

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