The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

Daisuke Izawa and Jonathon Pines ()
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Daisuke Izawa: Tennis Court Road, Cambridge CB2 1QN, UK
Jonathon Pines: Tennis Court Road, Cambridge CB2 1QN, UK

Nature, 2015, vol. 517, issue 7536, 631-634

Abstract: By binding and inhibiting a second CDC20 molecule, the mitotic checkpoint complex can convert a local ‘wait’ signal from unattached kinetochores to inhibit the anaphase promoting complex/cyclosome throughout the cell and avoid premature cell division.

Date: 2015
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DOI: 10.1038/nature13911

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