Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury

Andrew E. Vaughan (), Alexis N. Brumwell, Ying Xi, Jeffrey E. Gotts, Doug G. Brownfield, Barbara Treutlein, Kevin Tan, Victor Tan, Feng Chun Liu, Mark R. Looney, Michael A. Matthay, Jason R. Rock and Harold A. Chapman ()
Additional contact information
Andrew E. Vaughan: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Alexis N. Brumwell: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Ying Xi: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Jeffrey E. Gotts: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Doug G. Brownfield: Stanford University School of Medicine and Howard Hughes Medical Institute
Barbara Treutlein: Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
Kevin Tan: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Victor Tan: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Feng Chun Liu: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Mark R. Looney: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Michael A. Matthay: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Jason R. Rock: School of Medicine, University of California, San Francisco (UCSF), San Francisco, California 94143, USA
Harold A. Chapman: Cardiovascular Research Institute, University of California, San Francisco (UCSF), San Francisco, California 94143, USA

Nature, 2015, vol. 517, issue 7536, 621-625

Abstract: Lineage-tracing experiments identify a rare, undifferentiated population of quiescent cells in the mouse distal lung that are activated through a Notch signalling pathway to repair the epithelium after bleomycin- or influenza-mediated injury; inappropriate Notch signalling may be a major contributor to failed regeneration within the lungs of patients with chronic lung disease.

Date: 2015
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DOI: 10.1038/nature14112

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