MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

Christopher J. Cheng, Raman Bahal, Imran A. Babar, Zachary Pincus, Francisco Barrera, Connie Liu, Alexander Svoronos, Demetrios T. Braddock, Peter M. Glazer, Donald M. Engelman, W. Mark Saltzman and Frank J. Slack ()
Additional contact information
Christopher J. Cheng: Cellular and Developmental Biology, Yale University
Raman Bahal: Yale University
Imran A. Babar: Cellular and Developmental Biology, Yale University
Zachary Pincus: Cellular and Developmental Biology, Yale University
Francisco Barrera: Yale University
Connie Liu: Cellular and Developmental Biology, Yale University
Alexander Svoronos: Yale University
Demetrios T. Braddock: Yale University
Peter M. Glazer: Yale University
Donald M. Engelman: Yale University
W. Mark Saltzman: Yale University
Frank J. Slack: Cellular and Developmental Biology, Yale University

Nature, 2015, vol. 518, issue 7537, 107-110

Abstract: A novel anti-microRNA delivery platform that targets the acidic tumour microenvironment, in which a chosen anti-miRNA is coupled to a peptide that can transport the anti-miRNA across cell membranes specifically in an acidic environment.

Date: 2015
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DOI: 10.1038/nature13905

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