Recoded organisms engineered to depend on synthetic amino acids

Alexis J. Rovner, Adrian D. Haimovich, Spencer R. Katz, Zhe Li, Michael W. Grome, Brandon M. Gassaway, Miriam Amiram, Jaymin R. Patel, Ryan R. Gallagher, Jesse Rinehart and Farren J. Isaacs ()
Additional contact information
Alexis J. Rovner: Cellular and Developmental Biology, Yale University
Adrian D. Haimovich: Cellular and Developmental Biology, Yale University
Spencer R. Katz: Cellular and Developmental Biology, Yale University
Zhe Li: Cellular and Developmental Biology, Yale University
Michael W. Grome: Cellular and Developmental Biology, Yale University
Brandon M. Gassaway: Systems Biology Institute, Yale University
Miriam Amiram: Cellular and Developmental Biology, Yale University
Jaymin R. Patel: Cellular and Developmental Biology, Yale University
Ryan R. Gallagher: Cellular and Developmental Biology, Yale University
Jesse Rinehart: Systems Biology Institute, Yale University
Farren J. Isaacs: Cellular and Developmental Biology, Yale University

Nature, 2015, vol. 518, issue 7537, 89-93

Abstract: Construction of a series of genomically recoded organisms whose growth is restricted by the expression of essential genes dependent on exogenously supplied synthetic amino acids introduces novel orthogonal barriers between these engineered organisms and the environment, thereby creating safer genetically modified organisms.

Date: 2015
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DOI: 10.1038/nature14095

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