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Silylation of C–H bonds in aromatic heterocycles by an Earth-abundant metal catalyst

Anton A. Toutov, Wen-Bo Liu, Kerry N. Betz, Alexey Fedorov, Brian M. Stoltz () and Robert H. Grubbs ()
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Anton A. Toutov: California Institute of Technology
Wen-Bo Liu: California Institute of Technology
Kerry N. Betz: California Institute of Technology
Alexey Fedorov: California Institute of Technology
Brian M. Stoltz: California Institute of Technology
Robert H. Grubbs: California Institute of Technology

Nature, 2015, vol. 518, issue 7537, 80-84

Abstract: Carbon–hydrogen (C–H) bond functionalization catalysed by potassium tert-butoxide, which is abundant and inexpensive, offers a direct route to the silylation of aromatic heterocycles that both obviates the need for precious metal catalysts and overcomes the limitations of previous methods.

Date: 2015
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DOI: 10.1038/nature14126

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