Optogenetic control of organelle transport and positioning

Petra van Bergeijk, Max Adrian, Casper C. Hoogenraad () and Lukas C. Kapitein ()
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Petra van Bergeijk: Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
Max Adrian: Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
Casper C. Hoogenraad: Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
Lukas C. Kapitein: Cell Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands

Nature, 2015, vol. 518, issue 7537, 111-114

Abstract: An optogenetic strategy allowing light-mediated recruitment of distinct cytoskeletal motor proteins to specific organelles is established; this technique enabled rapid and reversible activation or inhibition of the transport of organelles such as peroxisomes, recycling endosomes and mitochondria with high spatiotemporal accuracy, and the approach was also applied to primary neurons to demonstrate optical control of axonal growth by recycling endosome repositioning.

Date: 2015
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DOI: 10.1038/nature14128

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