Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A

Qunfei Zhao, Min Wang, Dongxiao Xu, Qinglin Zhang and Wen Liu ()
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Qunfei Zhao: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Min Wang: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Dongxiao Xu: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
Qinglin Zhang: Huzhou Center of Bio-Synthetic Innovation, 1366 Hongfeng Road, Huzhou 313000, China
Wen Liu: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Nature, 2015, vol. 518, issue 7537, 115-119

Abstract: Mycothiol and ergothioneine are shown to have important roles in the biosynthesis of lincomycin A, a sulfur-containing antibiotic that is used to treat severe Gram-positive bacterial infections in people who cannot receive penicillin antibiotics.

Date: 2015
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DOI: 10.1038/nature14137

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