RNA helicase DDX21 coordinates transcription and ribosomal RNA processing

Eliezer Calo, Ryan A. Flynn, Lance Martin, Robert C. Spitale, Howard Y. Chang () and Joanna Wysocka ()
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Eliezer Calo: Stanford University School of Medicine
Ryan A. Flynn: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Lance Martin: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Robert C. Spitale: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Howard Y. Chang: Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine
Joanna Wysocka: Stanford University School of Medicine

Nature, 2015, vol. 518, issue 7538, 249-253

Abstract: DEAD-box RNA helicase DDX21 is involved in both the transcription and RNA processing of ribosomal genes in human cells, sensing the transcriptional status of both RNA polymerase I and RNA polymerase II and associating with non-coding RNAs involved in ribonucleoprotein formation, possibly allowing for coordinated regulation of protein synthesis.

Date: 2015
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DOI: 10.1038/nature13923

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