New genetic loci link adipose and insulin biology to body fat distribution

Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-Costa, Tamara S. Roman, Alexander W. Drong, Ci Song, Stefan Gustafsson, Felix R. Day, Tonu Esko, Tove Fall, Zoltán Kutalik, Jian’an Luan, Joshua C. Randall, André Scherag, Sailaja Vedantam, Andrew R. Wood, Jin Chen, Rudolf Fehrmann, Juha Karjalainen, Bratati Kahali, Ching-Ti Liu, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Georg B. Ehret, Mary F. Feitosa, Anuj Goel, Anne U. Jackson, Toby Johnson, Marcus E. Kleber, Kati Kristiansson, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Alena Stančáková, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Jana V. Van Vliet-Ostaptchouk, Loïc Yengo, Weihua Zhang, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Stefan Böhringer, Fabrice Bonnet, Yvonne Böttcher, Marcel Bruinenberg, Delia B. Carba, Ida H. Caspersen, Robert Clarke, E. Warwick Daw, Joris Deelen, Ewa Deelman, Graciela Delgado, Alex S. F. Doney, Niina Eklund, Michael R. Erdos, Karol Estrada, Elodie Eury, Nele Friedrich, Melissa E. Garcia, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Jagvir Grewal, Christopher J. Groves, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Kauko Heikkilä, Karl-Heinz Herzig, Quinta Helmer, Hans L. Hillege, Oddgeir Holmen, Steven C. Hunt, Aaron Isaacs, Till Ittermann, Alan L. James, Ingegerd Johansson, Thorhildur Juliusdottir, Ioanna-Panagiota Kalafati, Leena Kinnunen, Wolfgang Koenig, Ishminder K. Kooner, Wolfgang Kratzer, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Rebecca Mills, Alireza Moayyeri, Keri L. Monda, Simon P. Mooijaart, Thomas W. Mühleisen, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Ramaiah Nagaraja, Michael A. Nalls, Narisu Narisu, Nicola Glorioso, Ilja M. Nolte, Matthias Olden, Nigel W. Rayner, Frida Renstrom, Janina S. Ried, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Bengt Sennblad, Thomas Seufferlein, Colleen M. Sitlani, Albert Vernon Smith, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Andreas Tomaschitz, Chiara Troffa, Floor V. A. van Oort, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Roman Wennauer, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Qunyuan Zhang, Jing Hua Zhao, Eoin P. Brennan, Murim Choi, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, Ali G. Gharavi, Åsa K. Hedman, Marie-France Hivert, Jinyan Huang, Stavroula Kanoni, Fredrik Karpe, Sarah Keildson, Krzysztof Kiryluk, Liming Liang, Richard P. Lifton, Baoshan Ma, Amy J. McKnight, Ruth McPherson, Andres Metspalu, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, George Nicholson, Dale R. Nyholt, Christian Olsson, John R. B. Perry, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Eric E. Schadt, Robert A. Scott, Lisette Stolk, Edgar E. Vallejo, Harm-Jan Westra, Krina T. Zondervan, Philippe Amouyel, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Morris J. Brown, Michel Burnier, Harry Campbell, Aravinda Chakravarti, Peter S. Chines, Simone Claudi-Boehm, Francis S. Collins, Dana C. Crawford, John Danesh, Ulf de Faire, Eco J. C. de Geus, Marcus Dörr, Raimund Erbel, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Christian Gieger, Vilmundur Gudnason, Christopher A. Haiman, Tamara B. Harris, Andrew T. Hattersley, Markku Heliövaara, Andrew A. Hicks, Aroon D. Hingorani, Wolfgang Hoffmann, Albert Hofman, Georg Homuth, Steve E. Humphries, Elina Hyppönen, Thomas Illig, Marjo-Riitta Jarvelin, Berit Johansen, Pekka Jousilahti, Antti M. Jula, Jaakko Kaprio, Frank Kee, Sirkka M. Keinanen-Kiukaanniemi, Jaspal S. Kooner, Charles Kooperberg, Peter Kovacs, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loic Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Arthur W. Musk, Stefan Möhlenkamp, Andrew D. Morris, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Lyle J. Palmer, Brenda W. Penninx, Annette Peters, Peter P. Pramstaller, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Paul M. Ridker, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Peter E. H. Schwarz, Alan R. Shuldiner, Jan A. Staessen, Valgerdur Steinthorsdottir, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, Angelo Tremblay, Elena Tremoli, Marie-Claude Vohl, Uwe Völker, Peter Vollenweider, James F. Wilson, Jacqueline C. Witteman, Linda S. Adair, Murielle Bochud, Bernhard O. Boehm, Stefan R. Bornstein, Claude Bouchard, Stéphane Cauchi, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Richard S. Cooper, George Dedoussis, Luigi Ferrucci, Philippe Froguel, Hans-Jörgen Grabe, Anders Hamsten, Jennie Hui, Kristian Hveem, Karl-Heinz Jöckel, Mika Kivimaki, Diana Kuh, Markku Laakso, Yongmei Liu, Winfried März, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N. A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Pérusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo E. Saaristo, Danish Saleheen, Juha Sinisalo, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Thorsteinsdottir, Michael Stumvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Giovanni Veronesi, Mark Walker, Nicholas J. Wareham, Hugh Watkins, H-Erich Wichmann, Goncalo R. Abecasis, Themistocles L. Assimes, Sonja I. Berndt, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Lude Franke, Timothy M. Frayling, Leif C. Groop, David J. Hunter, Robert C. Kaplan, Jeffrey R. O’Connell, Lu Qi, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Cristen J. Willer, Peter M. Visscher, Jian Yang, Joel N. Hirschhorn, M. Carola Zillikens, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Caroline S. Fox, Inês Barroso, Paul W. Franks, Erik Ingelsson, Iris M. Heid, Ruth J. F. Loos, L. Adrienne Cupples, Andrew P. Morris, Cecilia M. Lindgren () and Karen L Mohlke ()
Additional contact information
Dmitry Shungin: Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
Thomas W. Winkler: Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Damien C. Croteau-Chonka: University of North Carolina
Teresa Ferreira: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Adam E. Locke: Center for Statistical Genetics, University of Michigan
Reedik Mägi: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Rona J. Strawbridge: Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Tune H. Pers: Boston Children's Hospital
Krista Fischer: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Anne E. Justice: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Tsegaselassie Workalemahu: Harvard School of Public Health
Joseph M. W. Wu: Boston University School of Public Health
Martin L. Buchkovich: University of North Carolina
Nancy L. Heard-Costa: National Heart, Lung, and Blood Institute, the Framingham Heart Study
Tamara S. Roman: University of North Carolina
Alexander W. Drong: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ci Song: Karolinska Institutet, Stockholm 17177, Sweden.
Stefan Gustafsson: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Felix R. Day: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Tonu Esko: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Tove Fall: Karolinska Institutet, Stockholm 17177, Sweden.
Zoltán Kutalik: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.
Jian’an Luan: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Joshua C. Randall: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
André Scherag: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, 45147 Germany.
Sailaja Vedantam: Boston Children's Hospital
Andrew R. Wood: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Jin Chen: University of Michigan
Rudolf Fehrmann: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Juha Karjalainen: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Bratati Kahali: University of Michigan
Ching-Ti Liu: Boston University School of Public Health
Ellen M. Schmidt: University of Michigan
Devin Absher: HudsonAlpha Institute for Biotechnology
Najaf Amin: Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Denise Anderson: Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia
Marian Beekman: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Jennifer L. Bragg-Gresham: Center for Statistical Genetics, University of Michigan
Steven Buyske: Rutgers University
Ayse Demirkan: Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Georg B. Ehret: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Mary F. Feitosa: Washington University School of Medicine
Anuj Goel: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Anne U. Jackson: Center for Statistical Genetics, University of Michigan
Toby Johnson: Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
Marcus E. Kleber: Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Kati Kristiansson: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Massimo Mangino: King’s College London, London SE1 7EH, UK.
Irene Mateo Leach: University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Carolina Medina-Gomez: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Cameron D. Palmer: Boston Children's Hospital
Dorota Pasko: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Sonali Pechlivanis: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, 45147 Germany.
Marjolein J. Peters: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Inga Prokopenko: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Alena Stančáková: University of Eastern Finland, FI-70210 Kuopio, Finland.
Yun Ju Sung: Washington University School of Medicine
Toshiko Tanaka: Translational Gerontology Branch, National Institute on Aging
Alexander Teumer: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Jana V. Van Vliet-Ostaptchouk: University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands.
Loïc Yengo: CNRS UMR 8199, F-59019 Lille, France.
Weihua Zhang: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
Eva Albrecht: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Johan Ärnlöv: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Gillian M. Arscott: PathWest Laboratory Medicine of Western Australia
Stefania Bandinelli: Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy.
Amy Barrett: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Claire Bellis: Texas Biomedical Research Institute
Amanda J. Bennett: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Christian Berne: Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden.
Matthias Blüher: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Stefan Böhringer: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Fabrice Bonnet: Inserm UMR991, University of Rennes, F-35000 Rennes, France.
Yvonne Böttcher: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Marcel Bruinenberg: LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Delia B. Carba: USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Ida H. Caspersen: Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Robert Clarke: Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK.
E. Warwick Daw: Washington University School of Medicine
Joris Deelen: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Ewa Deelman: Information Sciences Institute, University of Southern California
Alex S. F. Doney: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Niina Eklund: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Michael R. Erdos: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Karol Estrada: Broad Institute of the Massachusetts Institute of Technology and Harvard University
Elodie Eury: CNRS UMR 8199, F-59019 Lille, France.
Nele Friedrich: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Melissa E. Garcia: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Vilmantas Giedraitis: Geriatrics, Uppsala University, Uppsala 75185, Sweden.
Bruna Gigante: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Alan S. Go: Kaiser Permanente
Alain Golay: Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland.
Harald Grallert: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Jürgen Gräßler: University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Jagvir Grewal: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
Christopher J. Groves: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Toomas Haller: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Goran Hallmans: Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden.
Catharina A. Hartman: University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
Maija Hassinen: Kuopio Research Institute of Exercise Medicine, FI-70100 Kuopio, Finland.
Caroline Hayward: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
Kauko Heikkilä: University of Helsinki, FI-00014 Helsinki, Finland.
Karl-Heinz Herzig: Institute of Biomedicine, University of Oulu, FI-90014 Oulu, Finland.
Quinta Helmer: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Hans L. Hillege: University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Oddgeir Holmen: Norwegian University of Science and Technology, Trondheim 7489, Norway.
Steven C. Hunt: University of Utah
Aaron Isaacs: Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Till Ittermann: Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Alan L. James: Department of Pulmonary Physiology and Sleep Medicine
Ingegerd Johansson: Umeå University, 901 85 Umeå, Sweden.
Thorhildur Juliusdottir: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ioanna-Panagiota Kalafati: Harokopio University, 17671 Athens, Greece.
Leena Kinnunen: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Wolfgang Koenig: Ulm University Medical Centre, D-89081 Ulm, Germany.
Wolfgang Kratzer: Ulm University Medical Centre, D-89081 Ulm, Germany.
Claudia Lamina: Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria.
Karin Leander: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Nanette R. Lee: USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
Peter Lichtner: Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Lars Lind: Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Jaana Lindström: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Stéphane Lobbens: CNRS UMR 8199, F-59019 Lille, France.
Mattias Lorentzon: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
François Mach: Cardiology, Geneva University Hospital, Geneva 1211, Switzerland.
Patrik K. E. Magnusson: Karolinska Institutet, Stockholm 17177, Sweden.
Anubha Mahajan: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Wendy L. McArdle: School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Cristina Menni: King’s College London, London SE1 7EH, UK.
Sigrun Merger: Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Evelin Mihailov: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Lili Milani: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Alireza Moayyeri: King’s College London, London SE1 7EH, UK.
Keri L. Monda: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Simon P. Mooijaart: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Thomas W. Mühleisen: Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
Antonella Mulas: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche
Gabriele Müller: Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Martina Müller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Ramaiah Nagaraja: Laboratory of Genetics, National Institute on Aging
Michael A. Nalls: Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health
Narisu Narisu: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Nicola Glorioso: Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
Ilja M. Nolte: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Matthias Olden: Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Nigel W. Rayner: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Frida Renstrom: Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, 205 02 Malmö, Sweden.
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Neil R. Robertson: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Lynda M. Rose: Brigham and Women's Hospital
Serena Sanna: Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche
Hubert Scharnagl: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
Salome Scholtens: LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Bengt Sennblad: Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Thomas Seufferlein: Ulm University Medical Centre, D-89081 Ulm, Germany.
Colleen M. Sitlani: University of Washington
Albert Vernon Smith: Icelandic Heart Association, Kopavogur 201, Iceland.
Kathleen Stirrups: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Heather M. Stringham: Center for Statistical Genetics, University of Michigan
Johan Sundström: Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
Morris A. Swertz: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Amy J. Swift: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Ann-Christine Syvänen: Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
Bamidele O. Tayo: Stritch School of Medicine, Loyola University of Chicago
Barbara Thorand: German Center for Diabetes Research (DZD), D-85764 Neuherberg, Germany.
Gudmar Thorleifsson: deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Andreas Tomaschitz: Medical University of Graz, Graz 8036, Austria.
Chiara Troffa: Hypertension and Related Diseases Centre - AOU, University of Sassari Medical School, Sassari 07100, Italy.
Floor V. A. van Oort: Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands.
Niek Verweij: University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Judith M. Vonk: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Lindsay L. Waite: HudsonAlpha Institute for Biotechnology
Roman Wennauer: Ulm University Medical Centre, D-89081 Ulm, Germany.
Tom Wilsgaard: Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
Mary K. Wojczynski: Washington University School of Medicine
Andrew Wong: MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Qunyuan Zhang: Washington University School of Medicine
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Eoin P. Brennan: Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland.
Murim Choi: Seoul National University College of Medicine, Seoul 110-799, Korea.
Per Eriksson: Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Lasse Folkersen: Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Anders Franco-Cereceda: Cardiothoracic Surgery Unit, Karolinska Institutet, Stockholm 17176, Sweden.
Ali G. Gharavi: Columbia University College of Physicians and Surgeons
Åsa K. Hedman: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Marie-France Hivert: Harvard Pilgrim Health Care Institute, Harvard Medical School
Jinyan Huang: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Stavroula Kanoni: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Fredrik Karpe: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
Sarah Keildson: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Krzysztof Kiryluk: Columbia University College of Physicians and Surgeons
Liming Liang: Harvard School of Public Health
Richard P. Lifton: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA.
Baoshan Ma: Harvard School of Public Health
Amy J. McKnight: Nephrology Research, Centre for Public Health, Queen’s University of Belfast, Belfast, County Down BT9 7AB, UK.
Ruth McPherson: University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada.
Andres Metspalu: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Josine L. Min: School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Miriam F. Moffatt: National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Grant W. Montgomery: QIMR Berghofer Medical Research Institute
Joanne M. Murabito: National Heart, Lung, and Blood Institute, the Framingham Heart Study
George Nicholson: University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
Dale R. Nyholt: QIMR Berghofer Medical Research Institute
Christian Olsson: Cardiothoracic Surgery Unit, Karolinska Institutet, Stockholm 17176, Sweden.
John R. B. Perry: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Eva Reinmaa: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Rany M. Salem: Boston Children's Hospital
Niina Sandholm: Aalto University School of Science, FI-00076 Helsinki, Finland.
Eric E. Schadt: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Lisette Stolk: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Edgar E. Vallejo: Tecnológico de Monterrey, Atizapán de Zaragoza, 52926, Mexico.
Harm-Jan Westra: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Krina T. Zondervan: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Philippe Amouyel: Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France.
Dominique Arveiler: EA3430, University of Strasbourg, Faculty of Medicine
Stephan J. L. Bakker: University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
John Beilby: PathWest Laboratory Medicine of Western Australia
Richard N. Bergman: Cedars-Sinai Diabetes and Obesity Research Institute
John Blangero: Texas Biomedical Research Institute
Morris J. Brown: Clinical Pharmacology Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK.
Michel Burnier: Service of Nephrology, Lausanne University Hospital (CHUV), Lausanne 1005, Switzerland.
Harry Campbell: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Aravinda Chakravarti: Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
Peter S. Chines: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Simone Claudi-Boehm: Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
Francis S. Collins: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
Dana C. Crawford: Center for Human Genetics Research, Vanderbilt University Medical Center
John Danesh: University of Cambridge, Cambridge CB1 8RN, UK.
Ulf de Faire: Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
Eco J. C. de Geus: Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
Marcus Dörr: University Medicine Greifswald, D-17475 Greifswald, Germany.
Raimund Erbel: Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45122 Essen, Germany.
Johan G. Eriksson: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Martin Farrall: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Ele Ferrannini: University of Pisa, Pisa 56100, Italy.
Jean Ferrières: Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France.
Nita G. Forouhi: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Terrence Forrester: UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Oscar H. Franco: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Ron T. Gansevoort: University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Vilmundur Gudnason: Icelandic Heart Association, Kopavogur 201, Iceland.
Christopher A. Haiman: Keck School of Medicine, University of Southern California
Tamara B. Harris: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
Andrew T. Hattersley: Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
Markku Heliövaara: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Andrew A. Hicks: Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).
Aroon D. Hingorani: Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Wolfgang Hoffmann: Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
Albert Hofman: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Georg Homuth: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Steve E. Humphries: Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK.
Elina Hyppönen: Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.
Thomas Illig: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Marjo-Riitta Jarvelin: Imperial College London, London W2 1PG, UK.
Berit Johansen: Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Pekka Jousilahti: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Antti M. Jula: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Jaakko Kaprio: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Frank Kee: UK Clinical Research Collaboration Centre of Excellence for Public Health (NI), Queens University of Belfast, Belfast BT7 1NN, Northern Ireland, UK.
Sirkka M. Keinanen-Kiukaanniemi: Institute of Health Sciences, Faculty of Medicine, University of Oulu, FI-90014 Oulu, Finland.
Jaspal S. Kooner: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
Charles Kooperberg: Fred Hutchinson Cancer Research Center
Peter Kovacs: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Aldi T. Kraja: Washington University School of Medicine
Meena Kumari: University College London, London WC1E 6BT, UK.
Kari Kuulasmaa: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Johanna Kuusisto: Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Timo A. Lakka: Kuopio Research Institute of Exercise Medicine, FI-70100 Kuopio, Finland.
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Loic Le Marchand: Epidemiology Program, University of Hawaii Cancer Center
Terho Lehtimäki: Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland.
Valeriya Lyssenko: Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.
Satu Männistö: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André Marette: Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec QC G1V 0A6, Canada.
Tara C. Matise: Rutgers University
Colin A. McKenzie: UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
Barbara McKnight: University of Washington
Arthur W. Musk: Sir Charles Gairdner Hospital
Stefan Möhlenkamp: Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45122 Essen, Germany.
Andrew D. Morris: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Mari Nelis: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Claes Ohlsson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
Albertine J. Oldehinkel: University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
Ken K. Ong: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Lyle J. Palmer: Epidemiology and Obstetrics & Gynaecology, University of Toronto, Toronto, Ontario M5G 1E2, Canada.
Brenda W. Penninx: Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University, 1081BT Amsterdam, The Netherlands.
Annette Peters: Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Peter P. Pramstaller: Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated Institute of the University of Lübeck, D-23562 Lübeck, Germany).
Olli T. Raitakari: Turku University Hospital, FI-20521 Turku, Finland.
Tuomo Rankinen: Human Genomics Laboratory, Pennington Biomedical Research Center
D. C. Rao: Washington University School of Medicine
Treva K. Rice: Washington University School of Medicine
Paul M. Ridker: Brigham and Women's Hospital
Marylyn D. Ritchie: Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Igor Rudan: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Veikko Salomaa: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Nilesh J. Samani: University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
Jouko Saramies: South Carelia Central Hospital, 53130 Lappeenranta, Finland.
Mark A. Sarzynski: Human Genomics Laboratory, Pennington Biomedical Research Center
Peter E. H. Schwarz: University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Alan R. Shuldiner: Diabetes and Nutrition, University of Maryland School of Medicine
Jan A. Staessen: Maastricht University, 6229 HA Maastricht, The Netherlands.
Valgerdur Steinthorsdottir: deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Ronald P. Stolk: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Konstantin Strauch: Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
Anke Tönjes: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Angelo Tremblay: Laval University, Quebec, QC G1V 0A6, Canada.
Elena Tremoli: Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy.
Marie-Claude Vohl: Institute of Nutrition and Functional Foods, Laval University, Quebec QC G1V 0A6, Canada.
Uwe Völker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
Peter Vollenweider: University Hospital (CHUV) and University of Lausanne, 1011, Switzerland.
James F. Wilson: Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Jacqueline C. Witteman: Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
Linda S. Adair: University of North Carolina
Murielle Bochud: Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.
Bernhard O. Boehm: Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.
Stefan R. Bornstein: University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
Claude Bouchard: Human Genomics Laboratory, Pennington Biomedical Research Center
Stéphane Cauchi: CNRS UMR 8199, F-59019 Lille, France.
Mark J. Caulfield: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
John C. Chambers: Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
Daniel I. Chasman: Brigham and Women's Hospital
Richard S. Cooper: Stritch School of Medicine, Loyola University of Chicago
George Dedoussis: Harokopio University, 17671 Athens, Greece.
Luigi Ferrucci: Translational Gerontology Branch, National Institute on Aging
Philippe Froguel: School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
Hans-Jörgen Grabe: University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.
Anders Hamsten: Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
Jennie Hui: PathWest Laboratory Medicine of Western Australia
Kristian Hveem: Norwegian University of Science and Technology, Trondheim 7489, Norway.
Karl-Heinz Jöckel: Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, Essen, 45147 Germany.
Mika Kivimaki: University College London, London WC1E 6BT, UK.
Diana Kuh: MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
Markku Laakso: Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
Yongmei Liu: Center for Human Genetics, Wake Forest School of Medicine
Winfried März: Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
Patricia B. Munroe: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Inger Njølstad: Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
Ben A. Oostra: Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Colin N. A. Palmer: Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
Nancy L. Pedersen: Karolinska Institutet, Stockholm 17177, Sweden.
Markus Perola: Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Louis Pérusse: Institute of Nutrition and Functional Foods, Laval University, Quebec QC G1V 0A6, Canada.
Ulrike Peters: Fred Hutchinson Cancer Research Center
Chris Power: Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
Thomas Quertermous: Stanford University School of Medicine
Rainer Rauramaa: Kuopio Research Institute of Exercise Medicine, FI-70100 Kuopio, Finland.
Fernando Rivadeneira: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Timo E. Saaristo: Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.
Danish Saleheen: University of Cambridge, Cambridge CB1 8RN, UK.
Juha Sinisalo: Helsinki University Central Hospital Heart and Lung Center, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.
P. Eline Slagboom: Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
Harold Snieder: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Tim D. Spector: King’s College London, London SE1 7EH, UK.
Unnur Thorsteinsdottir: deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Michael Stumvoll: Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
Jaakko Tuomilehto: National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
André G. Uitterlinden: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Matti Uusitupa: University of Eastern Finland, FI-70211 Kuopio, Finland.
Pim van der Harst: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Giovanni Veronesi: EPIMED Research Center, University of Insubria, Varese I-21100, Italy.
Mark Walker: Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK.
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
Hugh Watkins: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
H-Erich Wichmann: Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.
Goncalo R. Abecasis: Center for Statistical Genetics, University of Michigan
Themistocles L. Assimes: Stanford University School of Medicine
Sonja I. Berndt: National Cancer Institute, National Institutes of Health
Michael Boehnke: Center for Statistical Genetics, University of Michigan
Ingrid B. Borecki: Washington University School of Medicine
Panos Deloukas: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Lude Franke: University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Timothy M. Frayling: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
Leif C. Groop: Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
David J. Hunter: Brigham and Women's Hospital and Harvard Medical School
Robert C. Kaplan: Albert Einstein College of Medicine, Belfer 1306, New York 10461, USA.
Jeffrey R. O’Connell: Diabetes and Nutrition, University of Maryland School of Medicine
Lu Qi: Brigham and Women's Hospital and Harvard Medical School
David Schlessinger: Laboratory of Genetics, National Institute on Aging
David P. Strachan: St George's, University of London, London SW17 0RE, UK.
Kari Stefansson: deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
Cornelia M. van Duijn: Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
Cristen J. Willer: University of Michigan
Peter M. Visscher: Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Jian Yang: Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
Joel N. Hirschhorn: Boston Children's Hospital
M. Carola Zillikens: Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Elizabeth K. Speliotes: University of Michigan
Kari E. North: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Caroline S. Fox: National Heart, Lung, and Blood Institute, the Framingham Heart Study
Inês Barroso: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
Paul W. Franks: Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
Erik Ingelsson: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Iris M. Heid: Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
Ruth J. F. Loos: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
L. Adrienne Cupples: Boston University School of Public Health
Andrew P. Morris: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Cecilia M. Lindgren: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Karen L Mohlke: University of North Carolina

Nature, 2015, vol. 518, issue 7538, 187-196

Abstract: Abstract Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P

Date: 2015
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DOI: 10.1038/nature14132

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