Apico-basal forces exerted by apoptotic cells drive epithelium folding

Bruno Monier, Melanie Gettings, Guillaume Gay (), Thomas Mangeat, Sonia Schott, Ana Guarner and Magali Suzanne ()
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Bruno Monier: Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
Melanie Gettings: Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
Guillaume Gay: DamCB, Data Analysis and Modelling for Cell Biology, 13005 Marseille, France
Thomas Mangeat: Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
Sonia Schott: Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France
Ana Guarner: Centro de Biología Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autónoma de Madrid, Nicolás Cabrera 1, Cantoblanco, 28049 Madrid, Spain
Magali Suzanne: Université de Toulouse, UPS, LBCMCP, F-31062 Toulouse, France

Nature, 2015, vol. 518, issue 7538, 245-248

Abstract: Apoptotic cell death is required for morphogenesis of the developing leg joint of fruitflies; using this model system, the authors show here that within apoptotic cells a transient pulling force exerted through a highly dynamic apico-basal myosin II cable-like structure acts as a mechanical signal to increase tissue tension and modify tissue shape.

Date: 2015
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DOI: 10.1038/nature14152

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