Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Pedro A. Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M. Miller, Eros Lazzerini-Denchi and Agnel Sfeir ()
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Pedro A. Mateos-Gomez: Skirball Institute of Biomolecular Medicine, NYU School of Medicine
Fade Gong: Institute for Cellular and Molecular Biology, University of Texas at Austin. 2506 Speedway Stop A5000
Nidhi Nair: The Scripps Research Institute
Kyle M. Miller: Institute for Cellular and Molecular Biology, University of Texas at Austin. 2506 Speedway Stop A5000
Eros Lazzerini-Denchi: The Scripps Research Institute
Agnel Sfeir: Skirball Institute of Biomolecular Medicine, NYU School of Medicine

Nature, 2015, vol. 518, issue 7538, 254-257

Abstract: Next-generation sequencing technology is used to show that the error-prone polymerase θ (Polθ) is needed to promote alternative non-homologous end joining at telomeres, and during chromosomal translocations, while counteracting homologous recombination; inhibition of Polθ represents a potential therapeutic strategy for tumours that have mutations in homology-directed repair genes.

Date: 2015
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DOI: 10.1038/nature14157

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