Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

Peter Eirew, Adi Steif, Jaswinder Khattra, Gavin Ha, Damian Yap, Hossein Farahani, Karen Gelmon, Stephen Chia, Colin Mar, Adrian Wan, Emma Laks, Justina Biele, Karey Shumansky, Jamie Rosner, Andrew McPherson, Cydney Nielsen, Andrew J. L. Roth, Calvin Lefebvre, Ali Bashashati, Camila de Souza, Celia Siu, Radhouane Aniba, Jazmine Brimhall, Arusha Oloumi, Tomo Osako, Alejandra Bruna, Jose L. Sandoval, Teresa Algara, Wendy Greenwood, Kaston Leung, Hongwei Cheng, Hui Xue, Yuzhuo Wang, Dong Lin, Andrew J. Mungall, Richard Moore, Yongjun Zhao, Julie Lorette, Long Nguyen, David Huntsman, Connie J. Eaves, Carl Hansen, Marco A. Marra, Carlos Caldas, Sohrab P. Shah () and Samuel Aparicio ()
Additional contact information
Peter Eirew: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Adi Steif: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Jaswinder Khattra: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Gavin Ha: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Damian Yap: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Hossein Farahani: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Karen Gelmon: BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Stephen Chia: BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Colin Mar: BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Adrian Wan: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Emma Laks: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Justina Biele: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Karey Shumansky: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Jamie Rosner: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Andrew McPherson: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Cydney Nielsen: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Andrew J. L. Roth: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Calvin Lefebvre: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Ali Bashashati: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Camila de Souza: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Celia Siu: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Radhouane Aniba: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Jazmine Brimhall: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Arusha Oloumi: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Tomo Osako: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Alejandra Bruna: University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Jose L. Sandoval: University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Teresa Algara: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Wendy Greenwood: University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Kaston Leung: Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Hongwei Cheng: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Hui Xue: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Yuzhuo Wang: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Dong Lin: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Andrew J. Mungall: Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Richard Moore: Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Yongjun Zhao: Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Julie Lorette: Centre for Translational and Applied Genomics, BC Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Long Nguyen: University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
David Huntsman: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Connie J. Eaves: University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Carl Hansen: Centre for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
Marco A. Marra: Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Carlos Caldas: University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Sohrab P. Shah: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Samuel Aparicio: BC Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada

Nature, 2015, vol. 518, issue 7539, 422-426

Abstract: Deep-genome and single-cell sequencing analyses of patient-derived breast cancer xenografts reveal extensive, dynamic and reproducible changes in intra-tumoral mutational clonal composition on engraftment and serial propagation.

Date: 2015
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DOI: 10.1038/nature13952

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